Table 3 Change in pulmonary function after 60 days

VC_MAX%

Baseline

94.7 ± 10.0

94.8 ± 11.5

0.955

Day 60

98.0 ± 10.7

96.1 ± 11.0

0.475

(p’ = 0.001) ^b

(p’ = 0.123)

Change

2.3 (− 1.1, 5.9)

0.5 (− 1.1, 4.4)

0.192

FEV₁%

Baseline

91.4 ± 11.2

91.2 ± 12.4

0.941

Day 60

95.9 ± 11.9

92.6 ± 12.5

0.269

(p’ = 0.001) ^b

(p’ = 0.068)

Change

3.9 (1.5, 6.9)

1.7 (− 0.4, 3.1)

0.007^a

FEV₁/FVC

Baseline

79.5 ± 5.9

80.0 ± 7.9

0.773

Day 60

81.4 ± 5.4

79.8 ± 6.7

0.284

(p’ < 0.001) ^b

(p’ = 0.721)

Change

1.6 (0.5, 3.1)

0.8 (− 1.5, 1.3)

0.001^a

MMEF%

Baseline

68.4 ± 19.5

68.9 ± 22.8

0.928

Day 60

77.6 ± 18.1

70.6 ± 22.4

0.163

(p’ < 0.001) ^b

(p’ = 0.096)

Change

9.8 (3.8, 12.0)

2.2 (− 1.9, 5.8)

0.000^a

MVV %

Baseline

82.3 ± 16.7

82.2 ± 14.9

0.996

Day 60

92.9 ± 17.4

87.9 ± 16.9

0.230

(p’ < 0.001) ^b

(p’ = 0.001) ^b

Change

10.7 (4.1, 16.9)

3.5 (1.8, 9.2)

0.013^a

n = 34

n = 31

FeNO₅₀,

ppb

Baseline

19.5 (13.5, 26.5)

15.0 (12.0, 22.0)

0.161

Day 60

15.5 (11.8, 21.5)

14.0 (12.0, 21.0)

0.843

(p’ < 0.001) ^b

(p’ = 0.215)

Change

−3.0 (− 7.0, − 0.0)

−1.0 (− 2.8, 1.0)

0.041^a

FeNO₂₀₀,

ppb

Baseline

8.5 (6.0, 11.5)

8.0 (7.0, 12.0)

0.974

Day 60

7.5 (7.0, 11.5)

9.0 (6.0, 11.0)

0.521

(p’ = 0.100)

(p’ = 0.280)

Change

−1.0 (− 4.0, 1.3)

0.0 (− 2.8, 1.8)

0.647

CaNO,

ppb

Baseline

4.1 (1.9, 5.3)

4.8 (2.7, 5.0)

0.482

Day 60

3.3 (2.8, 4.3)

4.0 (3.1, 4.8)

0.229

(p’ = 0.064)

(p’ = 0.098)

Change

−1.1 (-2.2, 0.8)

−0.5 (− 2.3, 0.8)

0.857

BPT

n = 30

n = 30

Positive

Baseline

29 (96.7%)

26 (86.7%)

0.350

Day 60

17 (56.7%)

20 (66.7%)

0.302

(p’ < 0.001) ^b

(p’ = 0.067)

Change

12 (41.4%)

6 (23.1%)

0.149